Progressive renal disease is characterized by tubulo-interstitial injury with ongoing inflammation and fibrosis. The Nlrp3 inflammasome contributes to these pathophysiological processes through its canonical effects in cytokine maturation. Nlrp3 may additionally exert inflammasome-independent effects following tissue injury. https://www.ealisboa.com/top-offer-Birkenstock-Arizona-Eva-Beetroot-Purple-best-save/
Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction.
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