There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders. including Spinocerebellar Ataxia Type-3 (SCA3). Here. we augment the proteostasis network of Drosophila SCA3 models with Hsp104. https://www.thebanyantreers.shop/product-category/dinning-bench/
Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.
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